Adobe Acrobat Pro 9 has incorporated an accessibility checker that generates a report indicating whether that document is accessible or not. It even includes instructions on how to correct any element of the document that it finds to be inaccessible.

I saved a PowerPoint document as a PDF and then ran the accessibility checker. The report it generated helped me correct accessibility issues making it usable to screen reading software. Though Adobe does include a disclaimer that it may not find all the errors it gets us a lot closer to having compliant documents.

To see how it works for yourself - save a document as a PDF, then open in Adobe Acrobat Pro 9, click on the Advanced menu, and then Accessibility. I would suggest running the Full Check. Once it runs it will tell you that it has completed, click OK and then the report is generated conveniently to the side of the document so that you can make any needed changes.

For detailed instructions follow the link below:

Adobe Acrobat Pro 9 Accessibility Report Instructions